BIRTH ASPHYXIA · NEONATAL ENCEPHALOPATHY · HYPOXIC-ISCHEMIC ENCEPHALOPATHY
A physician-led, laboratory-verified treatment programme targeting the neurological consequences of oxygen deprivation — designed to support motor development, cognitive recovery and neuroplasticity based on the individual injury pattern, age and clinical profile of each patient.
Request Medical ConsultationAbout the Condition
Hypoxic-ischemic brain injury (HIE) occurs when the brain is deprived of adequate oxygen and blood flow. The resulting cellular damage triggers a cascade of neuronal death, white matter injury and chronic neuroinflammation that can persist long after the initial insult.
In neonates, HIE is most commonly caused by birth asphyxia — complications during labour and delivery that interrupt placental blood flow. In older children and adults, cardiac arrest, near-drowning, severe hypotension or perioperative complications can produce the same pattern of injury.
HIE is an acute injury with chronic consequences. The severity depends on the duration and degree of oxygen deprivation, the brain regions affected, and the age at which the injury occurred. Earlier intervention generally produces better clinical outcomes — the developing brain retains significant neuroplastic potential that diminishes over time.
Neonatal HIE (Birth Asphyxia)
The most common form, resulting from oxygen deprivation during labour, delivery or the immediate postnatal period. Affects 1–3 per 1,000 live births in developed countries. Severity is graded using the Sarnat classification (mild, moderate, severe). Motor, cognitive and developmental consequences depend on the extent and location of brain injury.
Cardiac Arrest HIE
Occurs in children or adults following cardiac arrest with prolonged cerebral hypoperfusion. The duration of circulatory arrest is the primary determinant of injury severity. Global cerebral ischaemia typically affects the hippocampus, basal ganglia and cortical watershed zones. Recovery potential depends on the interval between arrest and restoration of circulation.
Near-Drowning HIE
Results from submersion injury with prolonged hypoxia. Predominantly affects paediatric patients. The injury pattern is similar to cardiac arrest HIE but often involves additional hypothermia-related factors. Younger patients may retain greater neuroplastic recovery potential.
Perioperative HIE
Occurs as a complication of surgical procedures — typically cardiac surgery, major vascular surgery or procedures requiring prolonged anaesthesia. The injury mechanism involves transient cerebral hypoperfusion during or immediately after the procedure. Severity varies from focal deficits to diffuse cortical injury.
Our program is individually adapted for all subtypes and all stages of progression.
Important: Each patient is accepted into the programme only after a comprehensive individual medical assessment, which evaluates the nature and timing of the hypoxic-ischemic event, current neurological status, imaging findings and developmental trajectory.
The BioCells Program
Our HIE programme combines five biological components into a single personalised protocol. No two protocols are identical — each is constructed following a detailed medical evaluation of the patient's injury pattern, developmental status, age and clinical priorities.
Minimally invasive administration
Treatment is delivered by intravenous infusion or targeted local injection using specialised medical systems — not surgical instruments.
No general anaesthesia
Particularly important in paediatric HIE patients, where repeated anaesthesia exposure carries additional neurodevelopmental risks.
No risk of immune rejection
MSCs are immunoprivileged: they express low levels of HLA-I, lack HLA-II and carry a minimal risk of rejection whether the protocol is autologous or allogeneic. Allogeneic MSC protocols do not require immunosuppression.
Targets the biological mechanisms limiting recovery
Our protocol addresses chronic neuroinflammation, impaired myelination, excitotoxicity and oxidative stress — the persistent biological barriers to neurological recovery after hypoxic-ischemic injury.
Complements existing rehabilitation
Our programme works alongside ongoing physiotherapy, occupational therapy and developmental interventions. Patients do not need to discontinue any existing rehabilitation or medication.
Patients from around the world
We work with patients from around the world. Airport transfers, accommodation, visa support and multilingual coordination are included in every treatment programme.
What It Is
T-regs are specialised immune cells responsible for suppressing excessive inflammatory responses in the nervous system. After hypoxic-ischemic injury, the immune system often shifts into a chronically activated state that causes ongoing secondary damage to brain tissue.
How It Is Done
Delivered autologously (from the patient's own blood) or allogeneically (from a certified donor), based on the patient's age, immune status and clinical assessment. Preparation and quality testing performed in our laboratory.
Biological Mechanisms
How This Helps in Hypoxic-Ischemic Brain Injury
The secondary injury phase in HIE is driven largely by excessive immune activation — microglia and infiltrating immune cells produce pro-inflammatory cytokines that damage tissue the initial hypoxic event left intact. T-regs directly counteract this process, limiting secondary damage and preserving the neural substrate needed for functional recovery.
Your Medical Board
The exact combination, dosage, sequencing and delivery method of all five components is determined individually by our medical board for each patient. No two treatment protocols are identical. Your programme is constructed based on your specific injury pattern, neurological status, age, biological markers and clinical priorities.
Your protocol is designed individually. Speak with our medical team to understand what your personalised program would include.
Request ConsultationPatient Journey
Your case is reviewed remotely by our physician team. We assess the nature and timing of the hypoxic-ischemic event, current neurological status, imaging findings and developmental trajectory. This consultation is free and carries no obligation.
A detailed review of all medical documentation — including MRI findings, developmental assessments and rehabilitation records. Our medical board evaluates eligibility, confirms safety parameters and designs your personalised therapeutic protocol.
Cells are collected, isolated, expanded and quality-tested in our laboratory. Each batch receives a full traceability certificate. This stage typically takes 2–3 weeks.
Cells are delivered by intravenous infusion or targeted local administration — no surgery, no general anaesthesia. Airport transfers, accommodation and visa support are included in the programme for international patients.
Structured rehabilitation sessions with our specialist, adapted to the patient's age, injury pattern and current functional level. Paediatric protocols incorporate developmental milestones and age-appropriate therapeutic approaches. Available at our clinic or remotely coordinated with your local medical team.
Your dedicated coordinator monitors neurological status, developmental progress and overall well-being. A medical-grade wearable bracelet supports continuous health tracking regardless of your location. Follow-up assessments are scheduled at regular intervals to document progress and guide ongoing care.
The first step is free. Request a medical consultation and our medical consultant will contact you within 24 hours.
Request ConsultationSafety Profile
Cellular therapy is considered safe when delivered under proper medical supervision and according to validated protocols. In our practice, the procedure is well-tolerated by both paediatric and adult HIE patients.
Temporary mild reactions — such as transient low-grade temperature, slight irritability in young children or mild fatigue — may occur in a minority of patients. These are typically short-lived and indicate active biological engagement.
A final medical assessment is performed on-site before every treatment session. If a patient's status has changed — including seizure activity or acute illness — the programme may be temporarily modified or postponed for safety reasons.
All contraindications are evaluated individually. A contraindication in one clinical context does not necessarily preclude treatment in a different context — this is always determined by physician assessment.
Standard Contraindications
Active acute infection or fever
Active malignancy or ongoing chemotherapy / radiotherapy
Severe decompensated cardiac or renal failure
Uncontrolled epileptic status (active seizure disorder must be stabilised prior to treatment)
Post-Treatment
Dedicated rehabilitation specialist
monitors motor development, cognitive milestones and overall neurological status
Personalised rehabilitation programme
adapted to the patient's age, injury pattern and current developmental stage
Medical-grade wearable monitoring
continuous physiological data collection supporting clinical decision-making
Long-term coordinator support
proactive check-ins, clinical guidance and response to any changes in status
Continued clinical access
our medical team remains available for ongoing reassessment and protocol adjustment
Neurological recovery after hypoxic-ischemic injury follows a non-linear trajectory. Biological repair processes — remyelination, synaptic reorganisation, resolution of chronic inflammation — require sustained clinical oversight. The post-treatment period is integral to the therapeutic programme.
Patient Stories
“Amir was eighteen months old and could not hold his head up. After the programme he started lifting it on his own during tummy time. His physiotherapist confirmed the change. Tone in his neck and trunk had improved. The gap between him and other children his age is closing rather than widening, and that distinction matters enormously to us.”
Patient's mother
Neonatal HIE (birth asphyxia) · UAE
Every case is assessed individually by our physician team. Request a consultation to discuss your specific situation with our physician team.
Request ConsultationPatient Cases
Documented treatment outcomes recorded by the BioCells Medical team after personalised regenerative medicine protocols.
Get Started
If your child or someone you love has been diagnosed with hypoxic-ischemic brain injury, our medical team is available for a free, no-obligation medical consultation — based on the diagnosis, current neurological status and individual clinical profile.
We review every inquiry personally. You will speak with a physician, not an administrator.
Submit your case online or by phone
Our medical consultant contacts you to review your documents
The medical board presents your personalised treatment plan
Request a Consultation
Tell us about your condition. Our medical consultant will contact you within 24 hours to review your documents.
Open Consultation FormMultilingual coordination — English, Italian, French, Russian, Polish
Evidence Base
Our clinical approach is informed by and consistent with published research in the field of regenerative medicine.
