ALS — Regained Movements and Improved Swallowing

Ilaria Baldi, a 43-year-old woman from Italy, was diagnosed with amyotrophic lateral sclerosis (ALS) in 2022. The initial presentation involved progressive weakness of the right hand. Over time, the condition led to increasing limitations in both upper and lower limb mobility, accompanied by difficulties with swallowing and reduced bulbar function. By the time she presented at BioCells Medical, the patient experienced significant challenges affecting motor control, daily activities, and overall functional independence.

• •Autologous mesenchymal stem cells (MSCs)
• •Autologous T-regulatory cells (Tregs)
• •Combined intravenous and intrathecal administration over two treatment days
• •Continuous medical supervision throughout the procedure

• •Ability to stand and take several supported steps
• •Notably clearer and more intelligible speech
• •Voluntary movements restored in the left hand and fingers
• •Improved strength and mobility of the right leg
• •Return of tongue mobility, which had been absent for several months
• •Restored ability to independently reposition in bed, including turning from supine to either side

Ilaria remains under ongoing medical observation following her first treatment cycle. Her neurological status and functional capacity continue to be monitored over time. Additional treatment cycles and supportive measures are being considered based on clinical evolution and patient-specific goals.

This clinical case illustrates the potential functional changes that may be observed following a personalised regenerative medicine approach in a patient with ALS. At BioCells Medical, each protocol is carefully adapted to the individual patient's condition, disease stage, and medical profile, with close medical supervision throughout the process. Because ALS presents differently in each individual, all patients are assessed on a case-by-case basis to determine the most appropriate medical strategy.