POST-POLIOMYELITIS SYNDROME · LATE EFFECTS OF POLIO · PPS
A physician-led, laboratory-verified treatment programme designed to support surviving motor neurons, reduce progressive fatigue and stabilise neuromuscular function — tailored to the individual biology, disease severity and clinical profile of each post-polio patient.
Request Medical ConsultationAbout the Condition
Post-Polio Syndrome (PPS) is a progressive neuromuscular condition that develops decades after the initial poliovirus infection — typically 15 to 40 years later. It affects an estimated 25–40% of polio survivors worldwide.
During the original infection, the poliovirus destroyed a significant proportion of spinal motor neurons. The surviving neurons compensated by sprouting new axonal branches to reinnervate orphaned muscle fibres. For years or decades, this compensatory mechanism maintained functional muscle strength. PPS occurs when these overworked surviving motor neurons begin to fail under chronic metabolic overload — leading to new or worsening weakness, fatigue, muscle atrophy, and pain.
There is no approved pharmacological treatment for PPS. Standard medical management focuses on energy conservation, assistive devices and symptom relief. Our programme targets the underlying biological mechanisms — mitochondrial dysfunction in remaining motor units, chronic neuroinflammation, and progressive denervation — to support the survival of these critical remaining neurons.
Post-Polio Muscular Atrophy
Characterised by progressive new weakness and muscle wasting in previously affected and sometimes previously unaffected limbs. Reflects ongoing degeneration of overloaded motor neurons and loss of reinnervated motor units. Typically presents with measurable decline on Manual Muscle Testing over months to years.
Post-Polio Fatigue Syndrome
Predominant symptom is severe, disabling central and peripheral fatigue disproportionate to physical activity. Related to mitochondrial dysfunction in surviving motor neurons and possible central nervous system involvement. Often the most functionally limiting aspect of PPS, affecting work capacity and daily independence.
Mixed Post-Polio Syndrome
Combination of progressive weakness, pathological fatigue and widespread musculoskeletal pain. Represents the majority of PPS presentations. Reflects multiple concurrent mechanisms — motor neuron overload, mitochondrial failure, chronic low-grade neuroinflammation, and secondary biomechanical stress.
Our program is individually adapted for all subtypes and all stages of progression.
Important: Each patient is accepted into the programme only after a comprehensive individual medical assessment, which evaluates original polio history, current neuromuscular status, respiratory function, and overall clinical profile.
The BioCells Program
Our post-polio programme combines five biological components into a single personalised protocol. Each protocol is constructed following a detailed medical evaluation of the patient's original polio history, current motor neuron reserve, fatigue profile and clinical priorities.
Minimally invasive administration
Treatment is delivered by intravenous infusion or targeted local injection using specialised medical systems — not surgical instruments.
No general anaesthesia
Important for post-polio patients, many of whom have compromised respiratory musculature from the original infection.
No risk of immune rejection
MSCs are immunoprivileged: they express low levels of HLA-I, lack HLA-II and carry a minimal risk of rejection whether the protocol is autologous or allogeneic. Allogeneic MSC protocols do not require immunosuppression.
Targets the underlying biology, not just symptoms
Rather than managing fatigue and weakness with energy conservation alone, our protocol targets mitochondrial dysfunction, neuroinflammation and motor neuron overload — the biological drivers of PPS progression.
Complements existing management
Our programme is compatible with existing physiotherapy, orthotic devices and pain management. Patients do not need to discontinue current care before commencing our protocol.
Patients from around the world
We work with patients from around the world. Airport transfers, accommodation, visa support and multilingual coordination are included in every treatment programme.
What It Is
T-regs are specialised immune cells that naturally suppress destructive inflammatory processes in the nervous system. They are the immune system's built-in mechanism for preventing excessive immune damage to healthy tissue.
How It Is Done
Delivered autologously (from the patient's own blood) or allogeneically (from a certified donor), based on the patient's immune status and clinical assessment. Preparation and quality testing performed in our laboratory.
Biological Mechanisms
How This Helps in Post-Polio Syndrome
Research indicates that PPS involves reactivation of inflammatory processes in the central nervous system — even decades after the original infection. Activated microglia and elevated inflammatory cytokines have been documented in the spinal cords of PPS patients. T-regs directly counteract this chronic inflammatory state, reducing collateral damage to the surviving motor neurons that the patient depends on for all remaining function.
Your Medical Board
The exact combination, dosage, sequencing and delivery method of all five components is determined individually by our medical board for each patient. No two treatment protocols are identical. Your programme is constructed based on your specific polio history, current motor neuron reserve, biological markers and clinical priorities.
Your protocol is designed individually. Speak with our medical team to understand what your personalised program would include.
Request ConsultationPatient Journey
Your case is reviewed remotely by our physician team. We assess your diagnosis, original polio history, current functional status and treatment goals. This consultation is free and carries no obligation.
A detailed review of all medical documentation — including original polio records where available, EMG/NCS results, and current PPL/MMT assessments. Our medical board evaluates eligibility, confirms safety parameters and designs your personalised therapeutic protocol.
Your cells are collected, isolated, expanded and quality-tested in our laboratory. Each batch receives a full traceability certificate. This stage typically takes 2–3 weeks.
Cells are delivered by intravenous infusion or targeted local administration — no surgery, no general anaesthesia. Airport transfers, accommodation and visa support are included in the programme for international patients.
Structured rehabilitation sessions with our specialist, adapted to your current motor capacity and fatigue tolerance. Post-polio rehabilitation requires careful calibration — overexertion accelerates motor neuron decompensation. Available at our clinic or remotely coordinated with your local medical team.
Your dedicated coordinator monitors functional status, fatigue levels and overall well-being. A medical-grade wearable bracelet supports continuous health tracking regardless of your location. Follow-up includes periodic MMT reassessment and PPL scoring.
The first step is free. Request a medical consultation and our medical consultant will contact you within 24 hours.
Request ConsultationSafety Profile
Cellular therapy is considered safe when delivered under proper medical supervision and according to validated protocols. In our practice, the procedure is well-tolerated by post-polio patients.
Temporary mild reactions — such as transient local discomfort at the infusion site, slight fatigue or low-grade temperature — may occur in a minority of patients. These are typically short-lived and indicate active immune engagement.
A final medical assessment is performed on-site before every treatment session. If a patient's status has changed — including respiratory function — the programme may be temporarily modified or postponed for safety reasons.
All contraindications are evaluated individually. A contraindication in one clinical context does not necessarily preclude treatment in a different context — this is always determined by physician assessment.
Standard Contraindications
Active acute infection or fever
Active malignancy or ongoing chemotherapy / radiotherapy
Severe decompensated cardiac or renal failure
Pregnancy
Post-Treatment
Dedicated rehabilitation specialist
monitors motor function, fatigue levels and overall well-being
Personalised rehabilitation programme
carefully calibrated to avoid overexertion, which accelerates motor neuron decompensation in PPS
Medical-grade wearable monitoring
continuous physiological data collection supporting clinical decision-making
Long-term coordinator support
proactive check-ins, clinical guidance and response to any changes in functional status
Continued clinical access
our medical team remains available for ongoing reassessment and protocol adjustment
Our approach is based on the principle that biological regeneration requires time, monitoring and adjustment. The period following treatment is as medically important as the treatment itself. Post-polio patients require particularly careful post-treatment calibration — balancing activity with recovery to protect surviving motor neurons.
Patient Stories
“The afternoon exhaustion was what finally broke me. I could not get through a single day without lying down by one o'clock. After the programme, that changed. Gradually at first, then clearly. I started finishing full days again. My legs feel steadier too. I walked to the market last week without stopping once.”
Patient
Post-Polio Syndrome (mixed type) · India
Every case is assessed individually by our physician team. Request a consultation to discuss your specific situation with our physician team.
Request ConsultationPatient Cases
Documented treatment outcomes recorded by the BioCells Medical team after personalised regenerative medicine protocols.
Get Started
If you or someone you love is living with post-polio syndrome, our medical team is available for a free, no-obligation medical consultation — based on your diagnosis, current functional status and individual clinical profile.
We review every inquiry personally. You will speak with a physician, not an administrator.
Submit your case online or by phone
Our medical consultant contacts you to review your documents
The medical board presents your personalised treatment plan
Request a Consultation
Tell us about your condition. Our medical consultant will contact you within 24 hours to review your documents.
Open Consultation FormMultilingual coordination — English, Italian, French, Russian, Polish
Evidence Base
Our clinical approach is informed by and consistent with published research in the field of regenerative medicine.
