POST-POLIOMYELITIS SYNDROME · LATE EFFECTS OF POLIO · PPS
A physician-led, laboratory-verified treatment programme designed to support surviving motor neurons, reduce progressive fatigue and stabilise neuromuscular function — tailored to the individual biology, disease severity and clinical profile of each post-polio patient.
Request Medical ConsultationAbout the Condition
Post-Polio Syndrome (PPS) is a progressive neuromuscular condition that develops decades after the initial poliovirus infection — typically 15 to 40 years later. It affects an estimated 25–40% of polio survivors worldwide.
During the original infection, the poliovirus destroyed a significant proportion of spinal motor neurons. The surviving neurons compensated by sprouting new axonal branches to reinnervate orphaned muscle fibres. For years or decades, this compensatory mechanism maintained functional muscle strength. PPS occurs when these overworked surviving motor neurons begin to fail under chronic metabolic overload — leading to new or worsening weakness, fatigue, muscle atrophy, and pain.
There is no approved pharmacological treatment for PPS. Standard medical management focuses on energy conservation, assistive devices and symptom relief. Our programme targets the underlying biological mechanisms — mitochondrial dysfunction in remaining motor units, chronic neuroinflammation, and progressive denervation — to support the survival of these critical remaining neurons.
Post-Polio Muscular Atrophy
Characterised by progressive new weakness and muscle wasting in previously affected and sometimes previously unaffected limbs. Reflects ongoing degeneration of overloaded motor neurons and loss of reinnervated motor units. Typically presents with measurable decline on Manual Muscle Testing over months to years.
Post-Polio Fatigue Syndrome
Predominant symptom is severe, disabling central and peripheral fatigue disproportionate to physical activity. Related to mitochondrial dysfunction in surviving motor neurons and possible central nervous system involvement. Often the most functionally limiting aspect of PPS, affecting work capacity and daily independence.
Mixed Post-Polio Syndrome
Combination of progressive weakness, pathological fatigue and widespread musculoskeletal pain. Represents the majority of PPS presentations. Reflects multiple concurrent mechanisms — motor neuron overload, mitochondrial failure, chronic low-grade neuroinflammation, and secondary biomechanical stress.
Our program is individually adapted for all subtypes and all stages of progression.
Important: Each patient is accepted into the programme only after a comprehensive individual medical assessment, which evaluates original polio history, current neuromuscular status, respiratory function, and overall clinical profile.
We do not offer a cure for post-polio syndrome. Our programme is designed to target the biological mechanisms driving progressive motor neuron failure — with the clinical objective of stabilising function, reducing fatigue burden, and preserving daily independence.
Clinical Outcomes
The following data are derived from structured observational analysis of patients treated at BioCells Medical. All figures represent aggregated clinical registry outcomes with longitudinal follow-up. Post-polio syndrome is a rare referral — our dataset reflects a smaller but carefully documented patient cohort. These are observational results — not randomised controlled trial data — and do not constitute a guarantee of therapeutic effect.
20
post-polio patients treated
70%
demonstrated measurable functional stabilisation within 3–6 months
65%
reported clinically meaningful reduction in fatigue severity
55%
showed improvement in at least one muscle group on MMT
60%
reported improved endurance during daily activities
Reduction in pathological fatigue during daily tasks
65%
Improved muscle endurance in previously weakened limbs
55%
Stabilisation of progressive weakness on MMT
70%
Reduced musculoskeletal pain intensity
50%
Improved walking distance or standing tolerance
45%
3–8 weeks
Initial functional response
3–6 months
Clinically meaningful change
1–2 years under continued monitoring
Functional stabilisation phase
Important: Outcomes depend on the extent of original motor neuron loss, current neuromuscular reserve, disease duration and individual biological response. Individual results may vary significantly.
Find out if our program can help in your specific case. The initial medical consultation is free and carries no obligation.
Request ConsultationPatient Stories
“The afternoon exhaustion was what finally broke me. I could not get through a single day without lying down by one o'clock. After the programme, that changed. Gradually at first, then clearly. I started finishing full days again. My legs feel steadier too. I walked to the market last week without stopping once.”
Patient
Post-Polio Syndrome (mixed type) · India
Every case is assessed individually by our physician team. Request a consultation to discuss your specific situation with our physician team.
Request ConsultationThe BioCells Program
Our post-polio programme combines five biological components into a single personalised protocol. Each protocol is constructed following a detailed medical evaluation of the patient's original polio history, current motor neuron reserve, fatigue profile and clinical priorities.
No surgery required
Treatment is delivered by intravenous infusion or targeted local injection using specialised medical systems — not surgical instruments.
No general anaesthesia
Important for post-polio patients, many of whom have compromised respiratory musculature from the original infection.
No risk of immune rejection — autologous option
Where clinically appropriate, we use the patient's own cells. Zero risk of graft-versus-host disease with autologous protocols.
Targets the underlying biology, not just symptoms
Rather than managing fatigue and weakness with energy conservation alone, our protocol targets mitochondrial dysfunction, neuroinflammation and motor neuron overload — the biological drivers of PPS progression.
Complements existing management
Our programme is compatible with existing physiotherapy, orthotic devices and pain management. Patients do not need to discontinue current care before commencing our protocol.
Treatment at your location worldwide
Our medical team is available to conduct treatment at our Warsaw clinic or to travel to the patient's location anywhere in the world. For older post-polio patients with mobility limitations, this removes a major barrier to accessing care.
What It Is
MSCs are multipotent regenerative cells with proven immunomodulatory and neuroprotective properties. They are among the most extensively studied cell types in regenerative medicine and have demonstrated safety across thousands of clinical applications worldwide.
How It Is Done
Cells are collected from the patient's own bone marrow (autologous, approximately 50 ml under local anaesthesia) or sourced from a certified donor (allogeneic), depending on individual clinical indications. All cells are then expanded, quality-controlled and tested in our certified Warsaw laboratory before administration.
Biological Mechanisms
How This Helps in Post-Polio Syndrome
In post-polio syndrome, the remaining motor neurons have been compensating for decades — operating at maximum metabolic capacity. MSCs provide direct neurotrophic support to these exhausted neurons, reduce the chronic low-grade inflammation present in the spinal cord, and create a more favourable biological environment for motor neuron survival. The goal is to slow decompensation and extend the functional lifespan of remaining motor units.
Your Medical Board
The exact combination, dosage, sequencing and delivery method of all five components is determined individually by our medical board for each patient. No two treatment protocols are identical. Your programme is constructed based on your specific polio history, current motor neuron reserve, biological markers and clinical priorities.
Your protocol is designed individually. Speak with our medical team to understand what your personalised program would include.
Request ConsultationPatient Journey
Your case is reviewed remotely by our physician team. We assess your diagnosis, original polio history, current functional status and treatment goals. This consultation is free and carries no obligation.
A detailed review of all medical documentation — including original polio records where available, EMG/NCS results, and current PPL/MMT assessments. Our medical board evaluates eligibility, confirms safety parameters and designs your personalised therapeutic protocol.
Your cells are collected, isolated, expanded and quality-tested in our certified Warsaw laboratory. Each batch receives a full traceability certificate. This stage typically takes 2–3 weeks.
Cells are delivered by intravenous infusion or targeted local administration — no surgery, no general anaesthesia. Treatment is available at our Warsaw clinic or with our medical team at your location worldwide. Airport transfers, accommodation and visa support are included in the programme. Where clinically appropriate, our medical board may approve a travelling treatment programme — our medical team flies directly to the patient.
Structured rehabilitation sessions with our specialist, adapted to your current motor capacity and fatigue tolerance. Post-polio rehabilitation requires careful calibration — overexertion accelerates motor neuron decompensation. Available at our clinic or remotely coordinated with your local medical team.
Your dedicated coordinator monitors functional status, fatigue levels and overall well-being. A medical-grade wearable bracelet supports continuous health tracking regardless of your location. Follow-up includes periodic MMT reassessment and PPL scoring.
The first step is free. Request a medical consultation and our medical consultant will contact you within 24 hours.
Request ConsultationSafety Profile
Cellular therapy is considered safe when delivered under proper medical supervision and according to validated protocols. In our practice, the procedure is well-tolerated by post-polio patients.
Temporary mild reactions — such as transient local discomfort at the infusion site, slight fatigue or low-grade temperature — may occur in a minority of patients. These are typically short-lived and indicate active immune engagement.
A final medical assessment is performed on-site before every treatment session. If a patient's status has changed — including respiratory function — the programme may be temporarily modified or postponed for safety reasons.
All contraindications are evaluated individually. A contraindication in one clinical context does not necessarily preclude treatment in a different context — this is always determined by physician assessment.
Standard Contraindications
Active acute infection or fever
Active malignancy or ongoing chemotherapy / radiotherapy
Severe decompensated cardiac or renal failure
Pregnancy
Post-Treatment
Dedicated rehabilitation specialist
monitors motor function, fatigue levels and overall well-being
Personalised rehabilitation programme
carefully calibrated to avoid overexertion, which accelerates motor neuron decompensation in PPS
Medical-grade wearable monitoring
continuous physiological data collection supporting clinical decision-making
Long-term coordinator support
proactive check-ins, clinical guidance and response to any changes in functional status
Continued clinical access
our medical team remains available for ongoing reassessment and protocol adjustment
Our approach is based on the principle that biological regeneration requires time, monitoring and adjustment. The period following treatment is as medically important as the treatment itself. Post-polio patients require particularly careful post-treatment calibration — balancing activity with recovery to protect surviving motor neurons.
Get Started
If you or someone you love is living with post-polio syndrome, our medical team is available for a free, no-obligation medical consultation — based on your diagnosis, current functional status and individual clinical profile.
We review every inquiry personally. You will speak with a physician, not an administrator.
Submit your case online or by phone
Our medical consultant contacts you to review your documents
The medical board presents your personalised treatment plan
Request a Consultation
Tell us about your condition. Our medical consultant will contact you within 24 hours to review your documents.
Open Consultation FormMultilingual coordination — English, Italian, French, Russian, Polish
Evidence Base
Our clinical approach is informed by and consistent with published research in the field of regenerative medicine.
