CONCUSSION · DIFFUSE AXONAL INJURY · POST-TRAUMATIC ENCEPHALOPATHY
A physician-led, laboratory-verified treatment programme targeting the secondary damage cascade, chronic neuroinflammation and impaired neuroplasticity that persist long after the initial injury — tailored to the individual injury profile, severity and functional deficits of each TBI patient.
Request Medical ConsultationAbout the Condition
Traumatic Brain Injury (TBI) is brain damage caused by an external mechanical force — a blow, blast, penetrating object or rapid acceleration-deceleration event. The initial injury triggers a cascade of secondary biological processes: neuroinflammation, axonal degeneration, blood-brain barrier disruption, excitotoxicity and mitochondrial dysfunction — all of which continue to damage neural tissue for months and years after the original trauma.
While the acute injury itself cannot be reversed, the chronic consequences of TBI — persistent cognitive deficits, headaches, emotional dysregulation, fatigue and reduced functional independence — are driven by ongoing biological processes that remain therapeutically accessible.
TBI affects an estimated 69 million people globally each year. Conventional rehabilitation addresses symptoms and compensatory strategies but does not target the underlying neuroinflammatory and degenerative mechanisms. Our programme is designed to intervene at this biological level — supporting axonal repair, reducing chronic inflammation and restoring conditions for neuroplasticity.
Mild TBI / Post-Concussion Syndrome
The most common form of TBI, often resulting from sports injuries, falls or minor vehicular accidents. Initial loss of consciousness is brief or absent. Many patients develop persistent post-concussion syndrome — chronic headaches, cognitive fog, light sensitivity, sleep disturbance and emotional lability lasting months to years beyond the initial event.
Moderate TBI
Characterised by prolonged loss of consciousness (minutes to hours) and post-traumatic amnesia lasting up to 24 hours. Patients frequently experience lasting deficits in memory, attention, processing speed and executive function. Recovery plateaus are common after conventional rehabilitation.
Severe TBI
Extended loss of consciousness (hours to weeks), significant structural brain damage visible on imaging. Patients may present with motor deficits, speech impairment, behavioural changes and reduced independence in daily activities. Long-term outcomes vary widely depending on injury location and extent of secondary damage.
Diffuse Axonal Injury (DAI)
Caused by rotational acceleration-deceleration forces that shear axonal connections across multiple brain regions. Often not visible on standard CT imaging. Results in widespread disruption of white matter tracts, leading to impaired information processing, slowed cognition, fatigue and difficulties with complex tasks requiring inter-regional brain communication.
Our program is individually adapted for all subtypes and all stages of progression.
Important: Each patient is accepted into the programme only after a comprehensive individual medical assessment, which evaluates injury severity, time since injury, current neurological status and overall clinical profile.
We do not claim to reverse the primary mechanical injury. Our programme targets the ongoing secondary biological processes — neuroinflammation, impaired neuroplasticity, white matter degeneration — with the clinical objective of improving cognitive function, reducing symptoms and restoring greater functional independence.
Clinical Outcomes
The following data are derived from structured observational analysis of patients treated at BioCells Medical between 2016 and 2025. All figures represent aggregated clinical registry outcomes with longitudinal follow-up. Assessments utilise the Glasgow Outcome Scale – Extended (GOS-E) and Disability Rating Scale (DRS). These are observational results — not randomised controlled trial data — and do not constitute a guarantee of therapeutic effect.
52
TBI patients treated
75%
demonstrated measurable functional improvement within 2–5 months
71%
showed improvement in at least one cognitive domain
68%
reported clinically meaningful reduction in headache frequency or severity
+1.2 pts
average GOS-E improvement at 5-month follow-up
65%
achieved sustained functional gains — follow-up to 2 years
Improved sustained attention and concentration
73%
Reduction in headache frequency or intensity
68%
Enhanced short-term and working memory
62%
Improved emotional regulation and reduced irritability
59%
Increased independence in daily activities
64%
2–4 weeks
Initial functional response
2–5 months
Clinically meaningful change
1–2 years under continued monitoring
Continued neuroplastic improvement
Important: Outcomes depend on injury severity, time elapsed since injury, extent of axonal damage, patient age and individual biological response. Individual results may vary significantly.
Find out if our program can help in your specific case. The initial medical consultation is free and carries no obligation.
Request ConsultationPatient Stories
“Jake couldn't follow a conversation with more than two people. He'd get lost in his own neighbourhood. Eighteen months after the accident, everyone said this was his new baseline. After treatment in Warsaw, he started remembering appointments on his own. The headaches went from daily to maybe twice a week. He's functioning again.”
Patient's mother
Severe TBI · USA
Every case is assessed individually by our physician team. Request a consultation to discuss your specific situation with our physician team.
Request ConsultationThe BioCells Program
Our TBI programme combines five biological components into a single personalised protocol. No two protocols are identical — each is constructed following a detailed medical evaluation of the patient's injury profile, neurological status, imaging findings and clinical priorities.
No surgery required
Treatment is delivered by intravenous infusion or targeted local injection using specialised medical systems — not surgical instruments.
No general anaesthesia
All procedures are performed without general anaesthesia — an important consideration for TBI patients who may have altered anaesthetic sensitivity.
No risk of immune rejection — autologous option
Where clinically appropriate, we use the patient's own cells. Zero risk of graft-versus-host disease with autologous protocols.
Targets the secondary damage cascade, not just symptoms
Our protocol addresses chronic neuroinflammation, blood-brain barrier dysfunction and impaired neuroplasticity — the biological drivers of persistent post-TBI deficits.
Effective at chronic stages
Unlike acute interventions with narrow time windows, cellular therapy targets biological processes that remain active months and years after injury — meaning patients can benefit regardless of time since the original trauma.
Treatment at your location worldwide
Our medical team is available to conduct treatment at our Warsaw clinic or to travel to the patient's location anywhere in the world.
What It Is
MSCs are multipotent regenerative cells with established immunomodulatory and neuroprotective properties. They are among the most extensively studied cell types in regenerative medicine, with demonstrated safety across thousands of clinical applications.
How It Is Done
Cells are collected from the patient's own bone marrow (autologous, approximately 50 ml under local anaesthesia) or sourced from a certified donor (allogeneic), depending on individual clinical indications. All cells are expanded, quality-controlled and tested in our certified Warsaw laboratory before administration.
Biological Mechanisms
How This Helps in Traumatic Brain Injury
After TBI, the brain enters a state of chronic neuroinflammation that persists long after the initial injury resolves. Activated microglia, elevated cytokines and sustained oxidative stress continue to damage viable neural tissue. MSCs directly suppress this inflammatory cascade, stabilise the peri-lesional environment and create biological conditions that support endogenous repair mechanisms — particularly in the tissue surrounding the primary injury site.
Your Medical Board
The exact combination, dosage, sequencing and delivery method of all five components is determined individually by our medical board for each patient. No two treatment protocols are identical. Your programme is constructed based on your specific injury profile, severity classification, time since injury, neuroimaging findings and clinical priorities.
Your protocol is designed individually. Speak with our medical team to understand what your personalised program would include.
Request ConsultationPatient Journey
Your case is reviewed remotely by our physician team. We assess your injury history, current neurological status, imaging data, medical records and treatment goals. This consultation is free and carries no obligation.
A detailed review of all medical documentation, neuroimaging and neuropsychological assessment results. Our medical board evaluates eligibility, confirms safety parameters and designs your personalised therapeutic protocol.
Your cells are collected, isolated, expanded and quality-tested in our certified Warsaw laboratory. Each batch receives a full traceability certificate. This stage typically takes 2–3 weeks.
Cells are delivered by intravenous infusion or targeted local administration — no surgery, no general anaesthesia. Treatment is available at our Warsaw clinic or with our medical team at your location worldwide. Airport transfers, accommodation and visa support are included in the programme. Where clinically appropriate, our medical board may approve a travelling treatment programme — our medical team flies directly to the patient.
Structured cognitive and physical rehabilitation sessions with our specialists, adapted to your specific deficits — attention, memory, executive function, motor coordination. Available at our clinic or remotely coordinated with your local rehabilitation team.
Your dedicated coordinator monitors cognitive and functional status, provides clinical guidance and adjusts recommendations based on your recovery data. A medical-grade wearable bracelet supports continuous health tracking regardless of your location.
The first step is free. Request a medical consultation and our medical consultant will contact you within 24 hours.
Request ConsultationSafety Profile
Cellular therapy is considered safe when delivered under proper medical supervision and according to validated protocols. In our practice, the procedure is well-tolerated by TBI patients across all severity grades.
Temporary mild reactions — such as transient local discomfort at the infusion site, slight fatigue or low-grade temperature — may occur in a minority of patients. These are typically short-lived and indicate active immune engagement.
A final medical assessment is performed on-site before every treatment session. If a patient's neurological status has changed — including seizure activity or acute complications — the programme may be temporarily modified or postponed for safety reasons.
All contraindications are evaluated individually. A contraindication in one clinical context does not necessarily preclude treatment in a different context — this is always determined by physician assessment.
Standard Contraindications
Active acute infection or fever
Active malignancy or ongoing chemotherapy / radiotherapy
Severe decompensated cardiac or renal failure
Uncontrolled post-traumatic epilepsy with frequent seizures
Pregnancy
Post-Treatment
Dedicated neurorehabilitation specialist
monitors cognitive, emotional and physical recovery milestones
Personalised cognitive rehabilitation programme
targeting attention, memory, executive function and processing speed
Medical-grade wearable monitoring
continuous physiological data collection supporting clinical decision-making
Long-term coordinator support
proactive check-ins, clinical guidance and response to any changes in status
Continued clinical access
our medical team remains available for ongoing reassessment and protocol adjustment
Neuroplastic recovery following TBI operates on a longer biological timeline than most patients expect. The period following treatment is as medically important as the treatment itself — continued monitoring, rehabilitation adherence and lifestyle adjustments directly influence the extent and durability of functional gains.
Get Started
If you or someone you love is living with the consequences of a traumatic brain injury, our medical team is available for a free, no-obligation medical consultation — based on your injury profile, current neurological status and individual clinical circumstances.
We review every inquiry personally. You will speak with a physician, not an administrator.
Submit your case online or by phone
Our medical consultant contacts you to review your documents
The medical board presents your personalised treatment plan
Request a Consultation
Tell us about your condition. Our medical consultant will contact you within 24 hours to review your documents.
Open Consultation FormMultilingual coordination — English, Italian, French, Russian, Polish
Evidence Base
Our clinical approach is informed by and consistent with published research in the field of regenerative medicine.
